Some blood-system stem cells reproduce more slowly than expected

first_imgA research collaboration lead by Harvard Stem Cell Institute researchers at Massachusetts General Hospital (MGH) has found a subpopulation of hematopoietic stem cells, which generate all blood and immune system cells, that reproduce much more slowly than previously anticipated.  Use of these cells may improve the outcome of stem cell transplants – also called bone marrow transplants – for the treatment of leukemia and other marrow-based diseases.  The report has been published on line by the journal Nature Biotechnology to coincide with a similar study in the journal Cell.“Hematopoietic stem cell transplantation saves many lives every day and is the most established therapeutic application of stem cells, but ironically we know very little about the cells that have made this clinical success possible,” says Harvard Medical School assistant professor Hanno Hock, MD, PhD, of HSCI and the MGH Center for Regenerative Medicine, who led the study.  “If we can improve our understanding of the biology of these cells, we should be able to offer our patients more therapeutic options.”It has been believed that the entire population of hematopoietic stem cells (HSCs) in the bone marrow reproduce at a rate of about 7 percent per day, with each cell dividing every two weeks.  But previous investigations of stem cell proliferation appear to have missed the fact that some cells divide much less frequently.  The MGH team developed a mouse model in which HSCs could be induced to express a green fluorescent label for a limited period of time.  Tracking how long cells retained the label after its expression was halted would indicate how long a cell remained in a resting phase between cell divisions. While 80 percent of the labeled HSCs were observed to proliferate at the expected rate, 20 percent of cells reproduced much more slowly, dividing once every 100 days or longer.  Another experiment found that a gene believed to keep HSCs in a resting state was not required to maintain the reduced rate of cell division in these slow-cycling HSCs, and a mathematical model of HSC proliferation only matched what was actually seen in the labeled mouse model if it assumed two populations of HSCs with differing rates of cell division.To test whether the rate of proliferation changed the cells’ ability to repopulate bone marrow, stem cell transplants were conducted using HSCs that had been labeled several months earlier and retained varying levels of the green marker – with higher label intensity signifying the slowly proliferating cells.  The best results were achieved with cells maintaining the most label, which would signify the slow-cycling population, while cells in which the label was weakest were least able to repopulate the animals’ marrow.“Our results suggest that we understand a lot less about HSCs than we thought,” Hock says.  “If we can find more markers for these slow-cycling cells and identify them in human bone marrow, we may be able to make more of them and find additional clinical applications.”   Co-lead authors of the report are Adlen Foudi, PhD, and Konrad Hochedlinger, PhD, of the MGH Center for Regenerative Medicine and Cancer Center.  Additional co-authors are Denille Van Buren and Jeffrey Schindler, MGH; Rudolf Jaenisch, MD, Whitehead Institute, and Vincent Carey, PhD, Harvard Medical School. The study was supported by grants from the Ellison Foundation, the Harvard Stem Cell Institute, the American Society for Hematology, the National Institute of Health, the Kimmel Foundation and the V Foundation.last_img read more

Chapels & Congregations

first_imgFort Hood is one of the most diverse and exciting places in the U.S. Army. As such, our chapels offer a variety of worship opportunities to fulfill the spiritual needs of our Soldiers and their Families. For information about chapel services and programs on Fort Hood, call the Fort Hood Garrison Chaplain’s Office at 254-288-6545.The chaplain’s program and ministries at Fort Hood have many dimensions. In addition to those described within this guide, there are prayer breakfasts, retreats, Bible studies, social events and special worship activities offered throughout the year. The Fort Hood Sentinel, the official newspaper of Fort Hood, features “Chapel Notes” regularly, listing the various chapel activities. If you are new to Fort Hood or looking for a spiritual home, we invite you to one of our chapel congregations.AWANAApproved Workmen Are Not Ashamed (AWANA) meets 3 to 5 p.m. Sunday at the Comanche Chapel. AWANA is open to youth ages 3 to 18. For more details, call 254-288-6545.CADENCE INTERNATIONALIn the Killeen/Fort Hood area, Cadence International sponsors the Soldier’s Hospitality House and the Fort Hood Hospitality House. The Soldier’s Hospitality House, 254-634-0822, is at 3981 Chaparral Road in Killeen. The Fort Hood Retreat Center and Hospitality House is at 485 County Road 4492, Kempner and is available for group retreats; call 512-932-2318. These groups are approved to meet on post and are supervised by the Installation Chaplain or designee.CHAPEL SERVICESFort Hood is home to many chapels sprinkled throughout unit areas. There are a variety of worship services available. During unit deployments, some chapels close. Check out the Fort Hood Sentinel for services, times and chapel locations, or call the Garrison Chaplain’s Office at 254-288-6545.BUDDHIST SERVICESBuddhist Temple Sungpulsal, 254-628-5595, is at 4600 Old Florence Road, Killeen. A Buddhist seminar is 7 p.m. Tuesday at the 19th Street Chapel.CATHOLIC SERVICESAll Catholic Services are at the 58th Street Chapel at the corner of 58th Street and Battalion Avenue.Daily MassNoon — Monday through Friday (except holidays)Saturday5 p.m. — MassSunday8 a.m. — Mass9:45 a.m. — Spanish Mass11:30 a.m. — English Mass2:30 p.m. — MassSpecifically for the benefit of mobilized Reserve and National Guard Soldiers; North Fort Hood Chapel on Highway 36 across from the North Fort Hood PX. Service times are subject to change because of training requirements.Confession4 to 4:45 p.m. Saturday, 58th Street Chapel (58th Street and Battalion Avenue) or by appointment, 254-288-6548.Fort Hood is blessed by the presence of a large number of volunteer organizations specializing in ministry to Soldiers and their Families. Inclusion in this context in no way constitutes endorsement by the Army.FORT HOOD OPEN CIRCLE (WICCA)The Fort Hood Open Circle meets at Camp Finlayson on West Fort Hood at 7:30 p.m. Tuesday.MUSLIM SERVICESServices are 1 p.m. Friday at the 76th Street Chapel. A dedicated prayer room is available during normal business hours for daily prayers. Contact the chapel at 254-288-7607 for more information. Muslim services are also available at the Islamic Center of Killeen, 5600 Highway 195 in Killeen; 254-634-8799.JEWISH SERVICESThe Jewish Congregation meets at 7 p.m. Friday and at 10 a.m. the first Saturday of the month at West Fort Hood Chapel.PROTESTANT SERVICESSunday ScheduleGeneral Protestant7 p.m.Specifically for the benefit of mobilized Reserve and National Guard Soldiers. North Fort Hood Chapel (Highway 36 across from the North Fort Hood PX). Service time is subject to change due to training requirements.Liturgical9 a.m. — 13 ESC Chapel(67th Street and Support Avenue)Lutheran9 a.m. — Old Post ChapelContemporary10:30 a.m. — West Fort Hood Chapel (Clarke Road and Headquarters Avenue)11 a.m. — 1st Cavalry Division Memorial Chapel (73rd Street and Battalion Avenue)5:30 p.m. — 1st Cavalry Division Memorial Chapel (73rd Street and Battalion Avenue)Gospel Services11 a.m. — Comanche ChapelEvangelical9 a.m. — Ironhorse Chapel(76th Street and Battalion Avenue)Protestant10 a.m. — 4th Infantry Division Memorial Chapel (25th Street and Battalion Avenue)Samoan Christian Worship2 p.m. — 1st Cavalry Division Memorial Chapel (73rd Street and Battalion Avenue)Traditional9 a.m. — Carl R. Darnall Army Medical Center Chapel (In the basement across from the dining facility)11 a.m. – 13 ESC Chapel(67th Street and Support Avenue)Protestant Women of the Chapel6 to 8 p.m. Monday; child care opens at 9 a.m. and program run 9:30 to 11:30 a.m. Tuesday (Free child care for ages 5 and under.)All women are invited. Meetings are at Comanche Chapel. Protestant Women of the Chapel offer the Fort Hood community group activities. Join PWOC for:Bible Studies: Apply God’s word to your life and learn more about Him and His will.Programs: Evangelical sessions that equip women for discipleship and fellowship.Worship, Praise and Prayer: Music that glorifies God, strengthens our relationship with Christ and uplifts the need of others.Outreach: Show the love of Jesus in a practical way.FAMILY MINISTRYThe Family Life Chaplain Training Center is a resource agency for chaplain-led Family ministry. The primary responsibility of the center is to offer training opportunities and resources to chaplains regarding marriage and Family counseling and enrichment programs. The center houses a book and video library addressing a variety of Family issues. The center offers pastoral counseling on a limited basis by referral from unit chaplains. For more information, visit the center in Building 21007 at the corner of 53rd Street and Old Ironsides Avenue. For more information, call 254-288-1757/1913.Training conducted by the Family Life Chaplain includes:Children-in-the-Middle: The second and fourth Wednesday of each month, 8 a.m. to noon. It is a four-hour program that teaches divorced or separating parents how to help their children cope with divorce. This course, or one like it, is mandatory for anyone pursuing divorce in Texas.Applied Suicide Intervention Skills Training (ASIST): ASIST is a two-day suicide intervention training program featuring basic intervention skills. It is designed to be the next step in the growth of the military’s prevention and intervention program. Participants attend two full days of training, which includes modules on suicide facts, caregiver attitudes, risk estimation, suicide intervention skills exercises and suicide resources in the community. More information about this training is available at the website of this internationally recognized program: Crisis Line: 254-287-CHAP (2427). The crisis hotline is an emergency service available 24/7. A chaplain is available to assist people in extreme emergencies. The chaplain on duty can help with spousal abuse, death of a Soldier or Family member, serious illness and suicide intervention.Counseling: The FLCTRC provides individual, couple, married and Family counseling to the Fort Hood Community. It is a training center focused on providing the best possible, most up-to-date and professional care in a confidential and safe environment.Family Wellness: 11:30 a.m. to 1 p.m. Tuesday. This program concentrates on developing skills in parenting, Family communication, change management and values in the Family. It is open to and appropriate for both single and dual-parent Families. Lunch is provided.Marriage 101: 9 a.m. to 3:30 p.m. first Wednesday of the month. This program provides committed couples specific communications skills and strategies to help them understand one another and strengthen or rekindle their friendship. Completion of this course is required to use a Fort Hood chapel for weddings. Lunch is provided.Pastoral Counseling: Fort Hood chaplains provide personal, marital and Family counseling. The counseling is offered within the context of religious and spiritual values. Appointments are arranged by calling your unit chaplain’s office. Counseling is considered as privileged information and is kept confidential.Referrals: Chaplains often work in conjunction with other installation agencies, including Army Community Services, health care professionals, Social Work Services and the Staff Judge Advocate attorneys. A chaplain can provide a critical link between a Soldier or Family member and these agencies.MILITARY COUNCIL OF CATHOLIC WOMENThe Fort Hood Military Council of Catholic Women (MCCW) is dedicated to bringing women of the community closer to the church and Christ through prayer, fellowship, Bible and book studies, ministering to the needs of the Fort Hood community and supporting parish programs. MCCW holds weekly meetings, beginning with the Rosary 9:30 to 11:30 a.m. every Wednesday at the Comanche Chapel. All women of the community are invited to join us. Free child care is provided for children 5 and under. Additionally, the council meets from 6:30 to 8:30 p.m. Monday at the 58th Street Chapel (58th Street and Battalion Avenue). There is no child care for evening meetings.NAVIGATORSThe Navigators sponsor a weekly Bible study at the 1st Cavalry Division Memorial Chapel at 7 p.m. Thursday.OFFICER’S CHRISTIAN FELLOWSHIPOfficer’s Christian Fellowship is active in the Fort Hood area. Their flagship Bible study is in the III Corps Headquarters Room E335.SOLDIER MINISTRYUnique to the Army is the availability of religious ministry at unit level. Every Soldier has a Unit Ministry Team (UMT), composed of a chaplain and a chaplain assistant, which provide counseling, religious activities and spiritual care. UMTs go where the Soldiers go. They accompany their units to the field, PT formations, eat in the dining facility and visit work areas. UMTs care about Soldiers. UMTs share Army and life experience with Soldiers: the heat, cold, hunger, weariness, mud — they are all part of the UMT’s job.SUNDAY SCHOOLPost-wide Sunday school meets at Comanche Chapel (on Tank Destroyer Boulevard west of Clear Creek Road) 9:30 to 10:30 a.m. every Sunday. For more information, call 254-288-6545.WEDDINGSFort Hood chapels are available for weddings and can be used by Soldiers and other authorized members of the Army Family at no cost. All weddings must have a sponsoring military chaplain, and all individuals are responsible for confirming reservations with the respective chapel NCOIC. Fort Hood chapel policy requires all couples marrying in a Fort Hood chapel to complete a premarital workshop provided by the Family Life Chaplain Training Center. Wedding licenses may be obtained from the Bell County extension office or the Coryell County extension office.last_img read more

`If you stay ready, you won’t have to get ready’

first_imgWhat do you do if you are a professional boxer and the gyms in your city/state are closed because of the COVID-19 pandemic? If you are Elton Dharry, you travel out of state to New Jersey and Pennsylvania a few times a week to put in work at the open gyms.Despite the COVID-19 restrictions on the hard hit state of New York, the Brooklyn based boxer is doing everything possible to stay in fight shape.“If you stay ready, you won’t have to get ready,” Dharry told Stabroek Sport yesterday. According to the 34 year-old, he is staying prepared for whenever an opportunity presents itself. He is willing to face any world champion that has a super flyweight belt. “I’m willing to take on any of the champions in my division from any organization WBC, WBO, WBA and IBF” Dharry stated.He was advised by his management team that there is a huge possibility that he will get a crack at a world title soon owing to the pandemic. Said Dharry, “The champions are not fighting each other and it’s hard to unify titles right now. Because of the virus, there are no ticket sales so promoters will be trying to get fighters in the top 15 to face their champions.”Dharry boasted that he is willing to step up to any challenge.Guyana’s most exciting super flyweight pugilist concluded that he could be in the ring as early as September perhaps in Panama once international travel to that territory resumes. Note: Dharry has a record of 24 wins (14 KOs), six losses and one draw. It is noteworthy that Dharry’s five losses occurred in the very early part of his career and he had not lost a fight since 2010; he had won his last 21 consecutive fights before suffering a controversial stoppage versus former World Boxing Association (WBA) champion, Andrew Moloney in the latter’s hometown of Melbourne, Australia last November.last_img read more

Penn State’s James Franklin vows to ‘vigorously defend’ program in wake of doctor’s allegations

first_imgPenn State Health, in its statement Monday, said the change in team doctors was made in the “best interests of student-athletes.””While we reject Dr. Lynch’s claims and will vigorously defend our program and its representatives, we remain grateful to him for his five years as director of athletic medicine for Intercollegiate Athletics and for his continued association with Penn State Health,” the statement said.No. 15 Penn State opens its season Saturday at home against Idaho. Penn State football coach James Franklin responded Tuesday to a lawsuit filed against him and the university that alleges he pressured a team doctor to clear players who were injured, saying “we’ll continue to vigorously defend our program” against allegations of wrongdoing.Speaking on his first weekly teleconference of the 2019 season, Franklin first referenced a statement issued Monday by Penn State Health, also named in the lawsuit, over former team orthopedic physician Scott A. Lynch’s suit that seeks $50,000 in damages. “Obviously I’d like to start with a statement rejecting Dr. Lynch’s claims,” Franklin said in his first public comments about the suit. “We’ll continue to vigorously defend our program and all participants in this manner. As always, the health and well-being of our student-athletes is of the utmost importance to us. But after that, we’ll have no further comment, so I just wanted to make sure we covered that.”In the lawsuit, Lynch claims Franklin attempted on “multiple and repeated occasions” to interfere with the doctor’s authority. Lynch said he was removed from his position as director of athletic medicine in March because of his complaints about Franklin’s alleged actions. Related News The lawsuit contends that Lynch was being punished for reporting Franklin to higher-ups and that constitutes violation of the Pennsylvania Whistleblower Law.A coach who interferes with a medical staff’s diagnoses or otherwise infringes on doctors’ autonomy also would be in violation of Big Ten and NCAA rules.The suit also claims Lynch was removed in an effort by Penn State to avoid scandal.center_img Wisconsin names Jack Coan as starting quarterback Florida band director attacked by Miami fan expected to be OKlast_img read more